If you’re a parent, you’ve no doubt come across this image…

peanut(Or any nut for that matter…)

Over the last few decades, the rise of peanut allergies in children has been called everything from a spike to an epidemic. Regardless of how you describe it, more kids than ever are at risk of a life-threatening situation.

The statistics don’t lie…

allergies(Pretty scary when you think about it…)

The reason for this increase is quite an enigma and researchers have been stymied by a lack of any strong connection between human behaviour and allergy occurrence.

However, there is one very interesting statistic most people don’t know. It can be best explained like this…

allergy-rise(A rainbow of risk…)

For some reason, allergies appear to be a problem only in certain regions of the world. More interesting, these areas are more developed, meaning they are richer and have improved standards for food, water, and sanitation safety.

While this may not sound any alarm bells, for certain researchers, this revelation can be best described as an…

ahamoment(A-Ha! Moment…)

Maybe…just maybe there is something in the food, water, or environment giving children in these less hygienic environments an added defense against allergy. If researchers could find that one factor, they might be able to find a way to ensure kids in the more developed countries don’t suffer.

The search has been going on for years and it appears one prime suspect has been found. It’s known as…

shistosoma(Schisto!)

Actually, it’s Schistosoma masoni and it’s better known as a blood fluke.

If you are up to date on your pathogenic microbiology – which I am sure you are – then you also know it’s a rather important infection causing diarrhea, abdominal pain, and an enlarged spleen. It’s prevalent in 78 different countries and up to 700 million people are at risk.

I can imagine what you’re thinking…

crazy(Unlike more cowbell…)

Yet, the signs have continued to point to worm exposure as the one reason children do not develop allergies.

If you happen to be fully versed in immunology – which again, I am sure you happen to be – then you might think of an explanation for this strange coincidence. As far-fetches as it may sound, there may be a protein in worms that helps to prevent peanut allergies.

For years, the usual reaction to this theory was…

twilight(It does not make a Serling argument…)

But, it seems the critics have been proven wrong. It’s all thanks to a recent paper entitled,

Antigenic cross‐reactivity between Schistosoma mansoni and peanut: a role for cross‐reactive carbohydrate determinants (CCDs) and implications for the hygiene hypothesis

You can read the whole paper by clicking on the link but as the name implies, the researchers have shown a link between Schistosoma and protection against allergies. It all comes down to a group of proteins known as glycoproteins.

If you happen to be an expert in organic chemistry – and let’s face it, who isn’t – then you know that this is a molecule containing both amino acids and sugars. These are relatively large molecules allowing them to take on a three-dimensional shape. Sometimes, that formation can appear to be like another completely different glycoprotein.

Here’s where it gets interesting…

When a glycoprotein enters the body, the immune system reacts to the visitation in one of a few ways. It can either recognize it as harmless and do nothing. It can distinguish it as a foe and attack. Or it can see it as a serious threat that needs to be expelled. This latter process is what is also known as an allergic response.

What the researchers found in this study is that the glycoprotein known to cause peanut allergies is very similar in formation to a harmless component found in worm eggs. However, the response to the egg is far more powerful than the peanut. This means having the eggs present in the gastrointestinal tract could ultimately block any response to peanuts.

At its core, this study suggests children should have Schistosoma worm eggs to prevent peanut allergies. Which probably leads to the following reaction…

interseting(Yet evil too…)

After all, no one wants to infect children and put them at risk just to prevent allergies.

Thankfully, there is an alternative option. The eggs can be rendered inert such that they cannot grow into worms. They then could be ingested without worry.

While this concept is still being tested in labs, the potential does appear to be real. If the results continue to be positive, we may even see clinical trials in the near future. The treatment may even reach the level of regulatory approval. Should this ever happen, we may one day be able to help children deal with allergies and never have to worry about a life-to-death situation again.

There is just one catch. Even if this idea gains widespread approval, don’t expect the worm eggs to be widely available. Unlike those other types of eggs…

breakfast(I always prefer sunny side up…)

These will only be available through a doctor.

Advertisements