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The Germ Guy: Confessions of a Mercurial Microbiologist

Music and the Microbe…

I didn’t post last week as I was in Finland for a series of lectures and meetings. It was a joyous time filled with science communication, advocacy and talks with some of the most wonderful people on the planet. I also had the chance to enjoy one of my most favorite foods…

(Salmon…)

Unlike what I can find in Canada, Finland offered a smorgasbord of different delights. All but one of my meals had some form of salmon. I relished every moment.

It’s one of the reasons I love travelling the world. I am given a chance to experience another society and appreciate the differences in tastes. Granted, most of the time this comes in the form of gastronomical choices.

But there is also another type of preference that changes every time I step in another country…

(Music…)

This is the band, Lordi. They are a heavy metal group known for winning the Eurovision contest a decade ago. Granted, not every Finnish person likes their style but if you happen to be going for Karaoke in Helsinki, you might want to learn their most favorite song, Hard Rock Hallelujah.

Musical choice is of course a personal one. If you ask any individual person about his or her preference in music, you may end up with a different answer each time. We tend to believe it is one of the unique aspects of being human…

(Think again…)

A fondness for music isn’t entirely a human trait. Believe it or not, music has an effect on many earthly creatures. As one saying suggests, it has the ability to calm even the most…

(Savage Beast…)

But for years we thought there was a limit. We held on to the notion music could not influence creatures who lack ears or any type of auditory nervous system.

But that changed back in 2010, thanks to a German company. They theorized bacteria could be influenced by music. The harmonic waves produced by the sound could convince these tiny creatures to work harder and accomplish more than expected.

The results were incredible. The bacteria thoroughly enjoyed the music and increased their activity. The door opened to a new type of human-microbial interaction through this form of artistic composition.

As to which artist the microbes liked best, as you might expect considering the location of the study, the answer was…

(Amadeus Amadeus!)

Now I’m sure you must be thinking there is something fishy going on here. Bacteria surely cannot distinguish musical notes, tones, or metres. There is no way they could prefer Mozart over say, Beethoven, Brahms, or…

(Beyonce…)

You would be correct. It took some time but last year, someone finally decided to put the musical preference theory to the test. The study, if you wish to read it, can be found here:
Effect of Audible Sound on Microbial Activity.

Instead of using music, the authors decided to test whether bacteria would grow in the presence of the most universal sound on the planet…

(Om…)

They tested the bacteria in the presence of this sound, as well as passages from Mozart’s The Magic Flute. If the authors were correct, there would be little to no difference between the two musical forms.

When the results came back, the team was happy to find out the answer was…

(Ya gotta respect the Master…)

There was little to no difference between the two sounds. If anything, the sound of ‘Om’ led to a slightly better performance from the bacteria. But the take home message was that bacteria liked music but had no real preferences.

The use of music as a means to improve microbial activity will continue no doubt. Researchers will continue to find the right combination of sound waves to bring out the best in bacteria. Eventually, the right combination will be found and I’m sure make for a great article and media story.

My only hope is that whomever conducts these tests in the future includes the music of one specific band…

(You had to see that coming…)

 

Why Spring May Tick You Off…

It’s that time of the year when the days last longer than the nights, the temperature warms, and many take a needed breath of relief. Winter has come to an end and we welcome the arrival of…

(Spring!)

From a health perspective, the change of season should signify a slowing down of the hectic pace caused by colds, flu, and other winter-associated illnesses. Yet, over the last decade, the stress has continued although the reason is far different.

Instead of the invisible bacteria and viruses causing all the trouble, another itchy subject has taken over as the public enemy Number 1…

(Ticks…)

As soon as the temperature holds steady at four degrees Celsius, these insects emerge from their hibernation and begin to forage for food. As you can imagine, after months of slumber, they are hungry for blood. They aren’t all that choosy either. If it’s filled with blood and has skin that is easy to penetrate, any animal – including a human – is fair game.

Ticks haven’t always been this troublesome as they used to be only present in woodlands and other rural areas. But they have claimed much more territory and call urban parks and other recreational gathering spaces home. How much you might ask…well, how about this…

(Don’t even ask to see the 2050 or 2080 estimates…)

Of course, the tick itself isn’t really the problem. Much like the mosquito, an invasion is little more than a nuisance that can quickly be remedied. But, inside many of these crawlers are microbes known to cause over a dozen different types of infections.

You may not have heard of some of the pathogens, such as Babesia, which causes anemia, or Powassan virus, which can cause fatal encephalitis. But I’m sure by now you know about the most common worry…

(Needless to say, it’s horrid…)

The mere threat of acquiring one of these infections may be enough to convince you to keep that bare skin covered or use insect repellents containing DEET. Yet, if this concern is not enough to take precautions, perhaps this might offer a good enough reason to keep these insects away…

(Welcome to the microscopic world…)

What you are looking at are the chelicerae (pronounced keh-lees-er-ay) of the tick. If you haven’t guessed what this particular appendage happens to accomplish, you might want to watch a certain video showing what it does. But before I show it, I have two quick notes.

First, this footage was made as a part of a scientific article examining how ticks actually manage to get into the skin. You can read it here:  How ticks get under your skin: insertion mechanics of the feeding apparatus of Ixodes ricinus ticks.

Second, if you happen to be squeamish in any way, you might want to forego watching the video. Although i find it fascinating, some people might consider it a little too um, well…

 (You get the idea…)

If you’re still willing, here’s the video in its entirety. It lasts for a few minutes but for those of you who really want to know how a tick begins its journey into the body, it’s worth the time.

 

Harnessing What Dogs Do Best To Save Lives…

Although I am more of a “cat person,” I concede dogs are incredible creatures. They love attention and return it in their own loving ways. They can be a person’s best friend as well as provide comfort to those who are truly in need.

The only drawback – if you can call it one – to these four-legged companions is their propensity to well…

(You get the idea…)

The reason behind this habit is biological in nature. The most important physiological signals are emitted from two organs known as the anal sacs. As the name implies, they are found in a rather discreet area of the body. When dogs want to learn more information about their counterpart, they attempt to find out using one of their most sensitive environmental detectors…

(The nose knows…)

For most of us, this activity may seem rather odd. But when you realize a dog’s sense of smell is hundreds of times more sensitive than humans (if not more), this is the perfect way to gain valuable information on a potential park mate.

It’s also far more effective than some other routes humans have chosen to acquire details on others such as…

(I spy…)

The olfactory superiority of dogs may be little more than a welcome piece of trivia for those moments when parties and get-togethers tend to drag on. But in 2012, a group of researchers in the Netherlands had a better use for this knowledge. The team wondered if those sensational snouts could be put to good use in a rather unlikely place…

(The hospital…)

The idea came as a result of a rather unfortunate reality occurring in health care. There was a significant rise in the number of infections caused by a pestering pathogen…

(Clostridium difficile…)

I’ve worked with this bacterium and I can tell you it has a rather unique smell. When you get to know the combination of different aromatics, you can identify it almost anywhere.

Now, as you might expect, for a human to pick up on the odour, the population needs to be in the billions, such as in a petri plate culture or from a human stool sample.

I know what you’re thinking…

(Believe me, it is…)

But for a dog, that smell may be picked up from far fewer numbers. Not to mention, the smell might be a whole new type of wonderful. It therefore should not surprise you to know when researchers went out to test their theory, the dog was…

(Happy to oblige…)

The end result was a rather interesting paper revealing a new means to identify C. difficile in healthcare facilities. You can read the study here:

Using a dog’s superior olfactory sensitivity to identify
Clostridium difficile in stools and patients: proof of principle study 

The paper was so warmly received that other institutions decided to use dogs to find the pathogen wherever it may be hiding. This included Vancouver General Hospital who recently added a new staff member to its infection prevention and control team…

(Angus…)

The spaniel has been working since November and has sniffed out dozens of C. difficile hiding spots. In each case, this happy-go-lucky worker has helped to keep hundreds of patients safe from the devious disease. His efforts have been so successful the hospital is looking to add more sniffing staff to its roster.

This is without a doubt one of those feel-good stories although for public health officials, the introduction of canine Clostridium hunters may lead to a different response…


(If you don’t get this, ask your parents…)

Considering this one bacterial species has become one of the greatest threats in healthcare facilities, any help to prevent its impact on patients is welcome news.

This story also offers one more benefit to those dog lovers out there. They finally may have a way to defuse those awkward situations when a cold nose happens to venture a little too close to certain sensitive zone…

(But it saves lives…)

Okay, maybe not…

A Hesitance in (Vaccine) Hesitancy…

If you happen to live in the United States or Canada, you’ve probably heard about the recent rise in cases of mumps or as some people like to call it…

(The Chubby Cheeks Virus…)

I’ve spoken on the virus quite a few times over the last month. Most of what I’ve said is summarized in my recent Huffington Post article, which you can read here:

Here’s The Reason Mumps Has Made A Comeback

As most people know, the best way to stay safe from this infection is vaccination. The mumps vaccine has been around for fifty years and continues to be the most effective means to keep the virus at bay.

But that doesn’t mean I am safe when I talk about these vaccine-preventable diseases. As per usual, I ensure I do my research on the history, the current situation, and any small details that could enrich the message.

Yet I also prepare for…

(A Battle of Words…)

Usually, as soon as I begin to promote vaccines, I can expect to be assailed by a small yet very vocal population of people who are against vaccination as a whole. There are a number of different names associated with these individuals but the most common in today’s scientific lingo is…

(Vaccine Hesitancy…)

The usual argument follows a similar script.

Me: Vaccines are effective.
Them: Vaccines are bad!
Me: Vaccines are safe.
Them: Vaccines are bad!
Me: Vaccines prevent infection
Them: Vaccines are bad!
(Repeat ad nauseum)

No matter what clinical evidence or molecular mechanism I provide, there is simply no room for these valuable medicines in their world. Eventually, the tone gets ugly and at times the attacks change from scientific to personal. At that point, there’s no other option than to…

(Give up the goose…)

As the mumps stories appeared, I readied myself for the assaults. I had all my arguments intact. Although the end result most likely would be a stalemate, I was prepared to go to social media war.

But something strange happened. Instead of flames and vitriol, the response to my efforts could be best described as…

(Crickets…)

There was no push back. There were no accusations of being a shill. The only comments I received shared thanks and appreciation. I even tried to stir the pot a little by spreading the word across different platforms. Yet still, there was no response. It’s as if there was hesitance in the hesitancy.

I know…

(Call it the Vinny Barbarino effect…)

I decided to ask around to find out if there were others feeling the effects of hesitancy but again, there was nothing. Instead, it seemed the advice to seek out vaccination against mumps was being left alone.

While I cannot say for sure what caused this lack of response to the mumps vaccine, I wonder if something else convinced them to stay clear of the issue. If I am right, then it may have something to do with a rather common symptom associated with infection…

(This is an actual ad…)

Maybe the fear of having excruciating pain in certain sensitive areas could overtake the urge to fight unwinnable battles. Perhaps the worry of infertility – for both men and women – could replace the baseless concerns over widespread vaccine harm. Or could it be that when it comes to an actual problem with lasting effects, such as diabetes and brain damage, people will turn to whatever works even if it goes against their principles?

In other words real fear may actually defeat…

(You get the idea…)

If this premise is correct, the result does leave a bitter taste. If the only way to gain the public’s trust is to scare them into acting on recommendations, we will continually need to have greater health threats in order to succeed. Granted, this may do some good in the short term but over the long haul, the efforts will end up hurting everyone. We’ll live in a continually worrisome society, which is as the hesitancy crowd would say…bad.

Not to mention, it may backfire such that we may have to worry about an even greater problem based on irrational fear. If you don’t believe me, let me bring back a word from a few years ago…

 (Need more be said?)

 

Worming Our Way Around Peanut Allergies…

If you’re a parent, you’ve no doubt come across this image…

peanut(Or any nut for that matter…)

Over the last few decades, the rise of peanut allergies in children has been called everything from a spike to an epidemic. Regardless of how you describe it, more kids than ever are at risk of a life-threatening situation.

The statistics don’t lie…

allergies(Pretty scary when you think about it…)

The reason for this increase is quite an enigma and researchers have been stymied by a lack of any strong connection between human behaviour and allergy occurrence.

However, there is one very interesting statistic most people don’t know. It can be best explained like this…

allergy-rise(A rainbow of risk…)

For some reason, allergies appear to be a problem only in certain regions of the world. More interesting, these areas are more developed, meaning they are richer and have improved standards for food, water, and sanitation safety.

While this may not sound any alarm bells, for certain researchers, this revelation can be best described as an…

ahamoment(A-Ha! Moment…)

Maybe…just maybe there is something in the food, water, or environment giving children in these less hygienic environments an added defense against allergy. If researchers could find that one factor, they might be able to find a way to ensure kids in the more developed countries don’t suffer.

The search has been going on for years and it appears one prime suspect has been found. It’s known as…

shistosoma(Schisto!)

Actually, it’s Schistosoma masoni and it’s better known as a blood fluke.

If you are up to date on your pathogenic microbiology – which I am sure you are – then you also know it’s a rather important infection causing diarrhea, abdominal pain, and an enlarged spleen. It’s prevalent in 78 different countries and up to 700 million people are at risk.

I can imagine what you’re thinking…

crazy(Unlike more cowbell…)

Yet, the signs have continued to point to worm exposure as the one reason children do not develop allergies.

If you happen to be fully versed in immunology – which again, I am sure you happen to be – then you might think of an explanation for this strange coincidence. As far-fetches as it may sound, there may be a protein in worms that helps to prevent peanut allergies.

For years, the usual reaction to this theory was…

twilight(It does not make a Serling argument…)

But, it seems the critics have been proven wrong. It’s all thanks to a recent paper entitled,

Antigenic cross‐reactivity between Schistosoma mansoni and peanut: a role for cross‐reactive carbohydrate determinants (CCDs) and implications for the hygiene hypothesis

You can read the whole paper by clicking on the link but as the name implies, the researchers have shown a link between Schistosoma and protection against allergies. It all comes down to a group of proteins known as glycoproteins.

If you happen to be an expert in organic chemistry – and let’s face it, who isn’t – then you know that this is a molecule containing both amino acids and sugars. These are relatively large molecules allowing them to take on a three-dimensional shape. Sometimes, that formation can appear to be like another completely different glycoprotein.

Here’s where it gets interesting…

When a glycoprotein enters the body, the immune system reacts to the visitation in one of a few ways. It can either recognize it as harmless and do nothing. It can distinguish it as a foe and attack. Or it can see it as a serious threat that needs to be expelled. This latter process is what is also known as an allergic response.

What the researchers found in this study is that the glycoprotein known to cause peanut allergies is very similar in formation to a harmless component found in worm eggs. However, the response to the egg is far more powerful than the peanut. This means having the eggs present in the gastrointestinal tract could ultimately block any response to peanuts.

At its core, this study suggests children should have Schistosoma worm eggs to prevent peanut allergies. Which probably leads to the following reaction…

interseting(Yet evil too…)

After all, no one wants to infect children and put them at risk just to prevent allergies.

Thankfully, there is an alternative option. The eggs can be rendered inert such that they cannot grow into worms. They then could be ingested without worry.

While this concept is still being tested in labs, the potential does appear to be real. If the results continue to be positive, we may even see clinical trials in the near future. The treatment may even reach the level of regulatory approval. Should this ever happen, we may one day be able to help children deal with allergies and never have to worry about a life-to-death situation again.

There is just one catch. Even if this idea gains widespread approval, don’t expect the worm eggs to be widely available. Unlike those other types of eggs…

breakfast(I always prefer sunny side up…)

These will only be available through a doctor.

Are Cell Phones Bringing Us Closer To The Post-Antibiotic Era?

Whenever there is a crisis, people start to play the blame by association game. It’s a natural process. But sometimes, the game gets a little…

preposterous(Out of hand…)

A perfect example of this happened a few weeks ago. In response to the antibiotic resistance crisis, a few researchers decided to publish a paper entitled…

Evaluation of the Effect of Radiofrequency Radiation Emitted From
Wi-Fi Router and Mobile Phone Simulator on the Antibacterial Susceptibility
of Pathogenic Bacteria Listeria monocytogenes and Escherichia coli

You can click on the title to read the whole study. But as the name implies, researchers have attempted to link the use of Wi-Fi and Mobile Phones to increasing rates of antibiotic resistance.

Just hearing this concept may make you want to say…

malarkey(Or balderdash for that matter…)

Yet, a few years ago, researchers did happen to notice an odd occurrence in bacteria placed in the presence of both Wi-Fi and cell phone radiation. The bacteria somehow gained the ability to resist antibiotics. At the time, it was considered to be a…

fluke(Fasciola hepatica to everyone else…) 

However, as with all experimental science, the results did create some interest and led to the aforementioned study.

The bacteria were placed in a zone where either Wi-Fi or cell phone radiation could be absorbed. At the same time, antibiotics were administered in an assay known as a…

zone-inhibition(Zone of Inhibition Test…)

Sensitivity and resistance are measured by the size of the zone of inhibition. The larger the diameter, the more sensitive the bacteria to the antibiotic. If there’s no zone, the bacteria are completely resistant.

The team focused on Escherichia coli and Listeria monocytogenes, two well known pathogens with a penchant for antibiotic resistance. No one actually expected the bacteria to gain resistance and yet…well, it gets weird…

ecoli-gsm
(This is E. coli in the presence of cell phone radiation…)

As you can see, the inhibition zone shrank for all the antibiotics after as little as three hours. This meant the bacteria had somehow figured out a way to resist the drugs. We’re not talking just penicillin but stronger types such as ciprofloxacin, or as we like to call it, cipro.

If you look at the 6 hour mark, you might decide the best thing to do is…

power-off(But can you get out of your contract?)

Mind you, this effect was short-lived. By 9 hours, the resistance began to wane and by 12 hours, there was no difference from the start of the test. As for the Wi-Fi, this is what the researchers observed…

ecoliwifi
(Not so bad…)

In contrast to the E. coli experiments, Listeria monocytogenes was not affected dramatically by the presence of either type of radiation. The bacteria seemingly had no radiation-resistance capability.

Usually when these studies come about, they fall into the type of category I like to call…

provocative(Or if you wish, intriguing…)

There was clearly some type of change going on in E. coli in the presence of cell phone radiation. Whatever it was somehow aided in resisting antibiotics.

This was not an evolutionary shift, mind you. It was instead a reaction to the presence of cell phone radiation. After getting used to the new environment, the bacteria went back to normal and started dying again.

From a microbiological perspective, this result definitely is worth following up. If we can figure out what is happening at the molecular level, we may be able to identify new coping mechanisms in the bacteria. We may also find new targets for therapy.

But in regards to the question posed in the title of this post, the best response happens to be…

no(Especially if you’re reading this post on your cell phone…)

Smog and Heartbreak in a Changing Climate…

One of the risks of science communication is the inevitable shift in topics to subjects considered to be politically sensitive. Usually, when these issues are brought up, people end up asking a universal question…

urkel(Or, are humans really to blame?)

Usually – and for some, unfortunately – the answer is yes. Mind you, scientists have been clever about hiding the blame behind jargon. For example, instead of saying certain troubles are due to humans, they tend to lay the blame on activities considered to be…

anthro(Which is a fancy word for “performed by humans”)

Sometimes, anthropogenic actions are easy to point out as the cause for troubles. In the last decade alone, our actions have led to…

  • The Ebola epidemic (hunting primates for food)
  • The cholera outbreak in Haiti (foreign rescue workers brought it in)
  • The influenza pandemic (high intensity farming)
  • SARS and MERS (co-habitation with viral vectors)

But when the conversation turns to a much more contentious topic, the mere inference of human fault can turn into…

fight(Trouble…)

There are many topics in which science and human interest collide. It’s also not new as this struggle has been going on in different forms for centuries. Topics such as evolution, the true source of certain diseases, and even the shape of the Earth – round or flat – has resulted in a conflict. But in this day and age, the most prevalent topic pitting the public against the scientist happens to be…

climate-change(The Earth is a changin’…)

Depending on the crowd, mention of this topic can quickly alter the atmosphere from clear, sunny, and calm to dark and gloomy with an excellent chance for verbal storms.

When people bring up the evil double-C, I tend to veer away from the debate as to whether the effects are indeed caused by humans. Instead, I like to discuss consequences of the Earth’s changing environment on our health. Regardless of the cause, we need to deal with the effects on us. I find taking this route helps to keep people calm and not end up…

angry(You get the idea…)

Over the years, I’ve used a number of examples to demonstrate the health effects of climate change without heading into the anthropogenic. Now it seems a new one has developed thanks to a paper released earlier this month. It focuses on a topic we all know and many of us have experienced. It’s a portmanteau of two words, “smoke,” and “fog.” Of course, I’m talking about…

to-cn-smog(Smog…and yes, that’s Toronto in the backdrop…)

Smog is the accumulation of tiny particles, about a millionth-of a metre in size. They float around in the air and obscure our ability to see great distances. As to the nature of those particles they vary but some of the substances can be described as…

chem_compo_pm_e(Nasty…)

When the body becomes exposed to these chemicals, the body ends up being rather unhappy. Most of the time, our focus is on the lungs and the impact on our ability to breathe. But there is another relatively unknown victim of smog…

heart(Cardiovascular health)

This may not seem a little strange considering the chemicals in smog don’t actually get into our blood. Yet, research has shown air pollution can contribute to poor heart health. As to how this happens, it all comes down to the immune system and, you know where this is going…

inflammation(When all else fails…blame inflammation…)

But while we can show smog is related to inflammation, we don’t have a good explanation as to how the immunological condition is initiated. This gap can be troublesome particularly when immersed in a climate change debate.

Now we may have an answer thanks to a fascinating scientific paper released last week. It’s called, Ambient Ultrafine Particle Ingestion Alters Gut Microbiota in Association with Increased Atherogenic Lipid Metabolites and if you click on the title, you can read the whole paper.

The researchers wanted to find out what could be the link between exposure to smog and the higher risk for cardiovascular problems. They could think of no better place to look than…

gut(The gut…and its microbes…)

Although the choice may seem strange, the rational made sense. Research had already shown a lack of proper diversity of the microbial population could lead to an increased risk for heart disease. Perhaps smog was somehow altering that diversity in the gut. All that was needed was to try…which they did…and subsequently found this…

inflammation(It’s pretty frightening…)

Okay, maybe it’s less frightening and more confusing without the appropriate background. Let me explain how the researchers got to this point…

The first step was to get some smog. This was not too difficult as they were located in the smog-capital of Los Angeles. After about a month, they had more than enough particles for the test.

Next, they needed some mice. They chose a strain known to be an excellent model for monitoring cardiovascular disease.

The third step was rather straightforward. They fed the mice the smog…

whatouse(What the…?)

Okay, perhaps this step doesn’t make much sense without context. When we inhale smog, it goes into our entire respiratory tract. Those particles end up trapped in our mucus, saliva, and other protective juices formed in our mouth, sinuses, throat, and lungs. When these surfaces are released, they only have two ways to go. One is out of the body…

spitting(Which may be socially unacceptable…)

The other is to swallow, which we all do at some point. As this happens, the smog particles eventually make their way to the gut where they may alter the normal function in the intestines. That’s why the mice were forced to eat smog.

The doses were similar to a normal smoggy day in LA. The animals were fed the same amount for a period of ten weeks. To ensure the situation closely mimicked humans living in LA, the mice also were fed a standard Western Diet. The only thing the researchers didn’t do was make the mice…

sunglasses(Look the part…)

At the end of the study, the mice were examined for any signs of inflammation. Which brings us back to the frightening figure…

inflammation(So you don’t need to scroll up…)

On the left, the team examined the intestinal cells of the mice and found a higher level of inflammation in those exposed to smog. On the right is an enumeration of inflammatory cells known as macrophages and neutrophils. In relation to the control, those exposed to smog (or as the authors called them, ultrafine particles or UFP), there were significantly more of both cell types.

As to why the inflammation was present, the team found a lack of microbial diversity in the gut. Once this was detected, the rest was simply a matter of putting the pieces of the puzzle together:

Diversity was down, thus inflammation was going to be up. Because inflammation was up, cardiovascular disease markers were going to be increased. When disease markers are higher, an individual is at a greater risk for a cardiovascular event.

The end result could be summed up in one very easy to say phrase…

unhappymouse(Smog Can Lead To Heartbreak…)

This study is fascinating on its own but for me, it offers yet more ammunition in climate change discussions. We now have a possible microbial link between smog and heart disease, making it easier to point out the effects of pollution on the body.

But more importantly, the information opens up a new direction for the debate. While we may haggle over the cause, we can provide some perspective on how we may be able to prevent the consequences. Put it this way…

If you want to keep your heart healthy, you can do one of two things…

  1. Get rid of the smog, in which you are a part of a global effort.
  2. Get rid of the diversity troubles, which is an individual effort comprised of changing your eating behaviour including reducing the sugars and fats, eating more fruits and vegetables, get those good probiotic bacteria, and increase the amount of that beneficial and yet horrid-tasting fibres.

When faced with these options, it’s incredible how people may decide to choose the global route over the individual one. After all, when faced with a decision, you can always count on people to choose…

easyway(Even if it means going against ideology…)

 

Watch What Happens When Immune Systems Attack!

Every now and then an article comes around that just fascinates me. A perfect example is the following paper from 2014…

Leukotriene B4 amplifies eosinophil accumulation in response to nematodes.

I know what you’re thinking…

awesome(Okay, maybe not…)

The study is actually pretty straightforward. It focuses on how a certain molecule, leukotriene B4, which is produced by a particular type of immune cell, an eosinophil, prompts other eosinophils to migrate to a particular enemy, in this case a parasitic worm. Simple, right?

sayagain(Okay, maybe not…)

The problem with a scientific article such as this one is the rather complex nature of the work and the mechanism the researchers discovered. Trying to explain this process could be an exercise in frustration. One needs to understand the cascade effect of immunity, the arachidonic acid biochemical pathway, and the biology of worms. Getting to the point could take as many or perhaps more words than the original article.

But there may be a better way to describe what is happening….

attack(You have to feel a little sorry for the worm…)

What you are seeing in this GIF is a time lapse video of eosinophils migrating towards a worm. Even more incredible is the length of time this video covers…only 80 minutes. In the context of the usually slow process by which biological life exists, this is what we call as fast as…

bolt(You get the idea…)

But while the rapid effect of a leukotriene on eosinophil migration in the battle against a worm may be just the bees knees for me, I can understand why this may not make you sit back in awe.

Of course, that is until I tell you there is a reason why you may find this information of interest. The same process witnessed above also happens when some people suffer…

asthma(Asthma or allergies or other respiratory distress…)

Even though the paper may not be worth the entire read, the GIF may be able to provide perspective on a significant health problem.

What I hope this also does is highlight the importance of fundamental research. While these types of studies may not seem to have any link to human health, when you widen the scope to what plagues us, then you may end up saying…

relevant(Even if the paper is upside down…)

After all, not all science is glamorous, but that doesn’t make it any less valuable.

Want To Remove Political Bias? Get ‘Em Curious…

There has been quite a bit of attention on science as of late. Granted, most of it has been negative; manifested in an ongoing backlash against recommendations made by scientists. No matter how much evidence is provided, there’s always that recurring refrain:

jerry(SHOW ME THE PROOF!)

I completely understand this sentiment. After all, science is not absolute and as such, has difficulties dealing with questions based on analysis. As researchers, we are trained to deal with these types of questions and find ways to respond to them accurately.

But the current situation is far worse. Instead of an argument of evidence vs evidence, questions are being asked based on fear, ideology, or what I consider to be the worst, political leanings. When this happens, a seed of doubt can quickly turn into an epidemic of distrust in the public. Most scientists are not ready for this type of dissent and many find themselves facing a…

mission-impossible-1(Mission Impossible…)

When you think about it, scientists are not alone. We are seeing similar actions against some of our most valued institutions such as the media, the justice system, and public health. In all of these cases, hard working people are doing their best to improve society and yet, at the end of the day, they always feel like they are…

money(Behind the 8-Ball)

In light of this, researchers have attempted to figure out how to dampen the fierce opposition, especially that which is not based on evidence and/or mechanisms. Unfortunately, in most cases, the results have suggested most strategies simply cannot get through the wall of politics. No matter how much scientists wish people would say it, in general, they are unwilling to state…

want-truth(I WANT THE TRUTH!) 

As to why people do not wish to learn more, you might say the answer is the same line you may have said to yourselves after seeing the above image…

handle(Which usually is the case…)

But researchers continue undeterred and finally it seems a group of researchers may have found one possible solution to this problem. The paper was published in the journal Political Psychology and as you might expect, goes after the concept of politics in the rejection of science.

You can read the whole article here: Science Curiosity and Political Information Processing but the answer is so simple, it could be considered laughable…

fashion(Unless you compare it to this…)

The team of researchers wanted to find out what could negate politically-motivated reasoning not based on evidence or mechanism. To do this, they first had to figure out what the difference was between normal reasoning and those based on political viewpoints. They provide a nice summary in this figure…

reasoning(Politics, um, trumps facts…)

This is troublesome to say the least because no matter how well scientists may communicate their views, they are destined to lose out because of those political predispositions. In order to succeed at gaining interest in science, something had to be done to negate the political viewpoints. But rather than use evidence, they decided to rely on something a little more…

risky(Risqué…work with me here…)

Instead of detailing evidence, such as those you might see in news stories, the team decided to go a different route. They wanted to offer something much more intrinsic to every human, regardless of political viewpoint. It’s been around for thousands of years and yet, from a scientific perspective, never seems to be a viable option when trying to convince people of the value of research. I’m talking about…

magnolia(Entertainment…)

The group asked volunteers to watch portions of scientific films with names such as, “Your Inner Fish,” “Darwin’s Dangerous Idea,” and “Mass Extinction: Life on the Brink.” The excerpts were chosen such that they wouldn’t overtly point to evidence or mechanisms. Rather, they would merely offer hints of the natural course of the world in the hopes of developing a sense of curiosity.

It was a gamble to say the least. After all, it could be disastrous to take a chance against the political grain…

lestat(Or the political fans for that matter…)

Yet, it worked. When people were asked about their curiosity on several politically-sensitive topics, climate change or fracking, individuals on both side of the spectrum seemed to have a similar patterns of interest.

But this wasn’t the real shocker. That came when the authors asked about the volunteers’ attitudes to these topics. Even the most die-hard conservatives changed their views in comparison to controls. Watching the films helped these individuals believe the concerns regarding these issues were real and without action, pose a threat to humanity.

For the authors, this was a complete surprise. By simply showing science in the form on entertainment, they had developed a change that was equivalent to…

knight-and-day(Okay, you can groan about this one…)

I admit, the results may seem incredible. Yet, from a purely human perspective, this should come as no surprise. No matter how deep political views may be entrenched, we all can be drawn from them through entertainment, particularly if it’s done well. Our belief system is hijacked by what we see and this can negate or at least lessen the impact of what is ingrained in us.

The results of this study reveal the importance of curiosity and entertainment in ensuring scientific success. However, there is one potential drawback to going the route of entertainment as opposed to evidence. No matter how slick and professional the output, there should always be a link back to the original research. If the public cannot identify the science within the style, then they may not realize why they are watching, listening, or reading. In essence, they might completely miss…

lessrossman
(Who the real actor may be…)

While this research may suggest going the entertainment route will lead to a more scientifically-based society, scientists also need to understand this approach can only go so far. Even though curiosity may help negate political bias, it may not be enough to get individuals to act in a manner that befits the concern. That will require a different type of convincing that so far, no one has figured out. But you can be sure, should that strategy every be found, those who come up with it will most definitely be considered at least in the scientific world…

topgun(I know you were waiting for it…)

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